Protein Details: Acid-sensing ion channel 3

Protein ID

ICDB_Pro_1122

Protein Name

Acid-sensing ion channel 3

Gene Name

Asic3; Accn3; Drasic

Organism

Mus musculus (Mouse)

Length

530 amino acids

AlphaFoldDB

AF-Q6X1Y6-F1-model_v4.pdb

Function

Cation channel with high affinity for sodium;which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic;damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

Sequence

MKPPSGLEEAQRRQASDIRVFANSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQVAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVIFTRMGQCYTFNSGAQGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASVDPDFDPEPSDPLGSPSSSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSETYITENVLVLDIFFEALNYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSSQRRSGNTLLQEELNGHRTHVPHLSLGPRPPTAPSAVTKTLAASHRTCYLVTRL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 26: "Potassium ion selectivity and permeability"

Disease

In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic; damaged or inflamed tissue

Location

Expressed in liver;lung;kidney;testis;brain;eye and cochlea. Expressed in spiral ganglion and sensory hair cells of the organ of Corti in the cochlea (at protein level). Expressed in dorsal root ganglion innervating muscles and spinal chord. Expressed in dorsal root ganglion innervating muscles and spinal chord. Expressed in dorsal root ganglion innervating muscles and spinal chord. Expressed in peripheral sensory nerve termimals like nerves of the Meissner corpuscle;palisades of lanceolate nerve endings;site of mechanoreception in guard hair follicles;and Merkel cell-neurite complexes

DOI ID

10.1016/s0378-5955(04)00015-2; 10.1371/journal.pbio.1000112; 10.1016/s0896-6273(00)81144-7; 10.1016/s0896-6273(01)00547-5; 10.1073/pnas.122245999; 10.1016/s0304-3959(03)00269-0; 10.1074/jbc.m405874200; 10.1074/jbc.m407708200; 10.1038/emboj.2012.203

RefSeq

NP_001297403.1 [Q6X1Y6-2]; NP_892045.2 [Q6X1Y6-1]